Vaterite microparticles stabilized by pamidronate were effective as 212Pb carriers labeling yields of ≥98% were achieved, and 212Pb was strongly retained by the particles in an in vitro stability assessment. In this work, we explored 212Pb-labeling of various CaCO 3 microparticles and developed a protocol that can be straightforwardly implemented by clinicians. Calcium carbonate may represent a suitable material, as it is biocompatible, biodegradable, and easy to synthesize. Another approach to exploiting the cytotoxic effect is coupling the radionuclide to a microparticle acting as a carrier vehicle, which could be used for treating disseminated cancers in body cavities. Many studies of 212Pb-labeling of various biomolecules through bifunctional chelators have been conducted. Lead-212 is recognized as a promising radionuclide for targeted alpha therapy for tumors.
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